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The number is expected to rise. In laboratories and in simple, small scale human trials, a generic must deliver the same active ingredient to the bloodstream of patients in virtually the same amount at virtually the same rate as the pioneer drug. They believe there are several potential flaws in the FDA’s standards of comparison, drug experts say. But sometimes patients and their doctors beg to differ. A switch from a long used brand name drug to its generic equivalent can, on occasion, bring a shifting profile of side effects.
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